Authors: Cody, W.L.; Lin, Z.; Panek, R.L.; Rose, D.W.; Rubin, J.R.

Source: Current Pharmaceutical Design, Volume 6, Number 1, 1 January 2000 , pp. 59-98(40)

Publisher: Bentham Science Publishers

Abstract:

SH2 domains are discrete structural motifs common to a variety of critical intracellular signaling proteins. Inhibitors of specific SH2 domains have become important therapeutic targets in the treatment and/or prevention of restenosis, cancers (including small cell lung), cardiovascular disease, osteoporosis, apoptosis among others. Considering the social and economic impact of these diseases significant attention has been focused on the development of potent and selective inhibitors of specific SH2 domains. In particular, considerable research has been performed on Src, PI 3-kinase, Grb2 and more recently, Lck. In this review, we will focus on progress in the development of inhibitors for these specific SH2 domains and evaluate potential future targets.

Keywords: inhibitors; SH2 Domains; signaling proteins; intracellular; restenosis; cancer; small cell lung; cardiovascular disease; Lck; apoptosis; osteporosis; Src PI3 kinase Grb2; receptor; tyrosine kinases RTK; Fgr; Yrk; Fyn; HcK; Blk; mechansims; platelet derived growth factor PDGF; hepatovyte; fibroblast growth factor FGF; epidermal; focal adhesion kinase; mitogen activated protein kinase; FAK; Cortactin

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1381612003401532

Publication date: 2000-01-01

More about this publication?

• Current Pharmaceutical Design publishes timely in-depth reviews covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area. A Guest Editor who is an acknowledged authority in a therapeutic field has solicits for each issue comprehensive and timely reviews from leading researchers in the pharmaceutical industry and academia.
  
  Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design, including: medicinal chemistry, pharmacology, drug targets and disease mechanism.

Related content

• In this: publication
• By this: publisher
• In this Subject: Pharmacology
• By this author: Cody, W.L. ;  Lin, Z. ;  Panek, R.L. ;  Rose, D.W. ;  Rubin, J.R.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers