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Regulation of Nociceptive Transmission at the Periphery Via TRPA1-TRPV1 Interactions

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TRPV1 and TRPA1 have traditionally been considered to function independently from each other as homomers, but their extensive co-expression in sensory neurons and recent evidence suggest that these channels can functionally interact and may form a complex as part of their normal function. Although TRPA1 and TRPV1 do not absolutely require interaction to maintain function in expression systems or even sensory neurons, their heteromerization may still result in dramatic effects on channel biophysical properties, pharmacology, signaling, regulation, and ultimately function. Understanding the regulation and functional significance of TRPA1-TRPV1 interaction is of tremendous clinical importance since first, both channels are the potential molecular targets for numerous therapeutic drugs; and second, TRPA1- TRPV1 co-expression is far more specific for nociceptive sensory neurons than expression patterns of TRPA1 or TRPV1 considered separately.

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Keywords: AM630; BK responses; BK-induced hyperalgesia; FRET interaction; I-RTX; PIP2; TIRF; TRP; TRP-like channels; TRPA1; TRPA1-TRPV1 complex; TRPL; TRPV1; TRPV1 Interactions; TRPV1-positive neurons; bradykinin; calcineurin; cannabinoid AM1241; cannabinoid-gated currents; capsazepine; channel blocker; co-immunoprecipitation; desensitization; inflammatory mediators; nerve growth factor; neurogenic inflammation; nociception; nociceptive transmission; nociceptors; nodose-petrosal ganglion complex; trigeminal ganglia

Document Type: Research Article

Publication date: 01 January 2011

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  • Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.
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