Methodological Considerations to Understand the Sensory Function of TRP Channels
Abstract:Transient Receptor Potential channels are exquisite molecular transducers of multiple physical and chemical stimuli, hence the raising interest to study their relevance to Sensory Biology. Here we discuss a number of aspects of the biophysical and pharmacological properties of TRP channels, which we consider essential for a clear understanding of their sensory function in vivo. By examining concrete examples extracted from recent literature we illustrate that TRP channel research is a field in motion, and that many established dogmas on biophysical properties, drug specificity and physiological role are continuously reshaped, and sometimes even dismantled.
Keywords: 1,4-dihydropyridines; CHEMOSENSORS; GABA; MO- or cinnamaldehyde- sensitive; NMDG+; PIP2-independent; Patch-Clamp Experiments; Quinine; Sensory Biology; TRP Channels; TRP-expressing neurons possess; TRPA1; TRPA1 activator MO; TRPA1 activator cinnamaldehyde; TRPA1 inhibitor HC-030031; TRPA1 modulators; TRPM8; TRPV1; TRPV3 2-aminoethoxydiphenyl borate; TRPs in certain; Transient Receptor Potential channels; acetyl choline receptors; alpha-hydroxy-sanshool; bradykinin; capsaicin; chemosensation; cinnamaldehyde; clotrimazole; complex endogenous modulation; desfluorane; drug specificity; high voltage-activated Ca2+; isofluorane; jugular ganglion neurons; lidocaine; menthol-sensitive neurons; methyl salicylate; nAChRs; nerve growth factor; neuro-inflammatory response; neurogenic inflammation; nicardipine; nicotine; nifedipine; nimodipine; nitrendipine; phosphatidylinositol-4,5-biphosphate; photometry; propofol; sensory neuron; somatosensation; visceral nociception
Document Type: Research Article
Publication date: 2011-01-01
- Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.