Skip to main content

Methodological Considerations to Understand the Sensory Function of TRP Channels

Buy Article:

$55.00 plus tax (Refund Policy)

Transient Receptor Potential channels are exquisite molecular transducers of multiple physical and chemical stimuli, hence the raising interest to study their relevance to Sensory Biology. Here we discuss a number of aspects of the biophysical and pharmacological properties of TRP channels, which we consider essential for a clear understanding of their sensory function in vivo. By examining concrete examples extracted from recent literature we illustrate that TRP channel research is a field in motion, and that many established dogmas on biophysical properties, drug specificity and physiological role are continuously reshaped, and sometimes even dismantled.

No References
No Citations
No Supplementary Data
No Article Media
No Metrics

Keywords: 1,4-dihydropyridines; CHEMOSENSORS; GABA; MO- or cinnamaldehyde- sensitive; NMDG+; PIP2-independent; Patch-Clamp Experiments; Quinine; Sensory Biology; TRP Channels; TRP-expressing neurons possess; TRPA1; TRPA1 activator MO; TRPA1 activator cinnamaldehyde; TRPA1 inhibitor HC-030031; TRPA1 modulators; TRPM8; TRPV1; TRPV3 2-aminoethoxydiphenyl borate; TRPs in certain; Transient Receptor Potential channels; acetyl choline receptors; alpha-hydroxy-sanshool; bradykinin; capsaicin; chemosensation; cinnamaldehyde; clotrimazole; complex endogenous modulation; desfluorane; drug specificity; high voltage-activated Ca2+; isofluorane; jugular ganglion neurons; lidocaine; menthol-sensitive neurons; methyl salicylate; nAChRs; nerve growth factor; neuro-inflammatory response; neurogenic inflammation; nicardipine; nicotine; nifedipine; nimodipine; nitrendipine; phosphatidylinositol-4,5-biphosphate; photometry; propofol; sensory neuron; somatosensation; visceral nociception

Document Type: Research Article

Publication date: 2011-01-01

More about this publication?
  • Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more