Development of an Artificial Chaperone System Based on Cyclodextrin

Authors: Sasaki, Yoshihiro; Akiyoshi, Kazunari

Source: Current Pharmaceutical Biotechnology, Volume 11, Number 3, April 2010 , pp. 300-305(6)

Publisher: Bentham Science Publishers

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Abstract:

Molecular chaperones in living systems inspired us to explore new concepts for assisting protein refolding. The chaperone selectively interacts with a non-native protein by hydrophobic interaction to prevent irreversible aggregation and releases the protein in its refolded form with the aid of ATP and another co-chaperone. Cyclodextrins have been used to simulate the function of the chaperones by controlling the hydrophobic interaction with proteins. In this chapter, we review the cyclodextrin (CD)-related protein refolding systems.





Keywords: Cyclodextrin; artificial chaperone; hydrophobized polymer; nanogel; surfactant

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/138920110791111951

Publication date: April 1, 2010

More about this publication?
  • Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.
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