Development of an Artificial Chaperone System Based on Cyclodextrin
Authors: Sasaki, Yoshihiro; Akiyoshi, Kazunari
Source: Current Pharmaceutical Biotechnology, Volume 11, Number 3, April 2010 , pp. 300-305(6)
Publisher: Bentham Science Publishers
Abstract:Molecular chaperones in living systems inspired us to explore new concepts for assisting protein refolding. The chaperone selectively interacts with a non-native protein by hydrophobic interaction to prevent irreversible aggregation and releases the protein in its refolded form with the aid of ATP and another co-chaperone. Cyclodextrins have been used to simulate the function of the chaperones by controlling the hydrophobic interaction with proteins. In this chapter, we review the cyclodextrin (CD)-related protein refolding systems.
Document Type: Research Article
Publication date: April 1, 2010
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