Recombinant Expression in Moderate Halophiles
A novel expression of recombinant proteins was developed using moderate halophiles that accumulate osmolytes and hence provide cytoplasmic environments where osmolyte-driven folding can take place. Promoters and selection marker were developed for high expression of foreign proteins. Examples are given for expression of bacterial nucleoside diphosphate kinase and human serine racemase.
Keywords: Soluble expression; compatible solute; kinase; moderate halophile; racemase
Document Type: Research Article
Publication date: 01 April 2010
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