Farnesyltransferase Inhibitors and Rapamycin in the Treatment of Multiple Myeloma
Authors: Zangari, Maurizio; Cavallo, Federica; Tricot, Guido
Source: Current Pharmaceutical Biotechnology, Volume 7, Number 6, December 2006 , pp. 449-453(5)
Publisher: Bentham Science Publishers
Abstract:Multiple myeloma (MM) is a B-cell malignancy characterized by an accumulation of long-lived neoplastic plasma cells (PC) within the bone marrow (BM). Novel treatments are not only targeting myeloma cells but also directly interfere with myeloma-stromal cell interactions, interrupting signal transduction pathways. Farnesyltransferase inhibitors (FTIs) and rapamycin represent novel classes of signal transduction inhibitors targeting principally Ras/MAPK and PI3K/Akt pathway. Pre-clinical and early clinical reports are presented in this study.
Document Type: Research article
Publication date: 2006-12-01
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