What We Learnt from Randomized Clinical Trials and Cohort Studies of Antioxidant Vitamin? : Focus on Vitamin E and Cardiovascular Disease

Authors: Ueda, Shinichiro; Yasunari, Kenichi

Source: Current Pharmaceutical Biotechnology, Volume 7, Number 2, April 2006 , pp. 69-72(4)

Publisher: Bentham Science Publishers

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Abstract:

There is no doubt that oxidative stress is pivotally involved in the process of atherosclerosis. Thus antioxidants, particularly vitamin E, have been expected to retard the development of atherosclerosis. In fact, several cohort studies suggested reduced cardiovascular risk in persons taking vitamin E supplements. However, randomized clinical trials of vitamin E did not show any benefit of vitamin E supplementation in terms of prevention of coronary heart disease and death. Discrepancy between cohort studies and randomized clinical trials may be partly explained by difference in coronary risk in study participant. However, use of vitamin E supplementation in low risk population has not been justified yet.

Keywords: Vitamin E; Antioxidants; Randomized clinical trials; Prevention; Coronary risk

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138920106776597649

Affiliations: 1: Department of Clinical Pharmacology and Therapeutics, University of the Ryukyus School of Medicine, Okinawa, 903-0251, Japan.

Publication date: 2006-04-01

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Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.