Bacteriophage Lambda as a Vehicle for Peptide and Protein Display

Author: Hoess R.H.

Source: Current Pharmaceutical Biotechnology, Volume 3, Number 1, March 2002 , pp. 23-28(6)

Publisher: Bentham Science Publishers

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Abstract:

Bacteriophage lambda has emerged as an alternative vehicle for the surface display of peptides and proteins to the commonly used filamentous phage. There are a number of unique features that make lambda an attractive display vehicle including the ability to display multimeric proteins, no requirement for secretion of the displayed fusion protein and the means to vary the valency of the displayed fusion protein. With its increasing use for cDNA encoded display, the lambda display systems will be an important tool for functional genomics.

Keywords: Bacteriophage Lambda; Cre recombinase; homeobox proteins EMX1; cDNA

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389201023378481

Publication date: 2002-03-01

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Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.