Phage Display as a Tool for Protease Ligand Discovery

Author: Nixon A.E.

Source: Current Pharmaceutical Biotechnology, Volume 3, Number 1, March 2002 , pp. 1-12(12)

Publisher: Bentham Science Publishers

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Abstract:

Proteolytic enzymes have been implicated as the pathological agent in a number of disease states. For this reason proteases are attractive therapeutic targets. Phage display of peptide libraries can be used to identify peptides that may be used either directly as inhibitors or serve as leads in the generation of prodrugs and peptidomimetics.

Keywords: Phage Display; Protease Ligand; peptidomimetics; Plasma kallikrein; chymotrypsin; allosteric mechanism

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389201023378526

Publication date: 2002-03-01

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Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.