Phage Displayed Biomolecules As Preventive and Therapeutic Agents

Authors: Manoutcharian K.; Gevorkian G.; Cano A.; Almagro J.C.

Source: Current Pharmaceutical Biotechnology, Volume 2, Number 3, September 2001 , pp. 217-223(7)

Publisher: Bentham Science Publishers

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Abstract:

Phage display is a powerful technology for selecting and engineering peptides and proteins expressed on the surface of filamentous bacteriophage. The advantages of phage display technology over other research tools and its great potential have been demonstrated by successful application of phage display in diverse fields of biomedical / clinical research. In this review we will describe some recent developments in phage display, including new expression vectors, display formats, bioselection strategies and applications in pharmaceutical biotechnology. We highlight some important applications of phage display to identify disease- and pathogen-specific biomolecules, making particular emphasis on development of phage display-derived preventive and therapeutic vaccines.

Keywords: phage display; phage immunogens

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389201013378671

Publication date: 2001-09-01

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Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.