Syntheses and Effect of Bombesin-Fragment6-14 and its Four Analogues on Food Intake in Rats

Authors: Abiko T.; Kimura Y.

Source: Current Pharmaceutical Biotechnology, Volume 2, Number 2, June 2001 , pp. 201-207(7)

Publisher: Bentham Science Publishers

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Abstract:

A nonapeptide, H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2 , corresponding to amino acids 6 to 14 of bombesin and its four analogues were synthesized by a solid-phase method and were tested for their comparative effect on reducing activity on food intake using male Wistar rats. The synthetic bombesin-fragment6- 14 showed reducing effect on food intake using male Wistar rats. Of the synthetic analogues, [Phe(4F)13 ]bombesin-fragment6-14 exhibited the most potent effect. The reducing effect on food intake of [Sar 11 ]bombesin-fragment6-14 was lower than that of our synthetic bombesin-fragment6-14, but the other two analogues, [beta Ala11]bombesin-fragment6-14 and [1-Nal8 ]bombesin-fragment6-14 showed no reducing effect on food intake in rats.

Keywords: Bombesin-Fragment6-14; Food Intake; nonapeptide, H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met; SOLID-PHASE PEPTIDE SYNTHESIS

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389201013378752

Publication date: 2001-06-01

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Current Pharmaceutical Biotechnology aims to cover all the latest and outstanding developments in Pharmaceutical Biotechnology. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics in both pre-clinical and clinical areas of Pharmaceutical Biotechnology. Current Pharmaceutical Biotechnology is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the latest and most important developments.