Author: Hiroyuki Kataoka

Source: Current Pharmaceutical Analysis, Volume 1, Number 1, January 2005 , pp. 65-84(20)

Publisher: Bentham Science Publishers

Abstract:

Sample preparation is essential for isolating desired components from complex matrices and greatly influences their reliable and accurate analysis. Solid-phase microextraction (SPME) is a new and effective sample preparation technique. Fibers and capillary tubes coated with an appropriate stationary phase are usually used for SPME, but alternative microextraction techniques, including solid-phase dynamic extraction using an internal coated needle, microextraction in a packed syringe and stir-bar-sorptive extraction using a coated magnetic stir bar, have been developed recently. These techniques, in combination with gas chromatography (GC), GC-mass spectrometry (GC-MS), high performance liquid chromatography (HPLC), LC-MS or capillary electrophoresis, can be used for analysis for complex mixtures. These microextraction techniques save preparation time, as well as solvent purchase and disposal costs. This review summarizes recent advances in SPME and related microextraction techniques and their applications in pharmaceutical and biomedical analysis.

Keywords: sample preparation for drug analysis; solid-phase microextraction; in-tube solid-phase microextraction; solid-phase dynamic extraction; microextraction in a packed syringe; stir-bar-sorptive extraction

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1573412052953373

Affiliations: 1: School of Pharmacy, Shujitsu University, Nishigawara, Okayama 703-8516, Japan.

Publication date: 2005-01-01

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• Current Pharmaceutical Analysis publishes authoritative reviews, written by experts in the field on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.

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