Recent Advances in Solid-Phase Microextraction and Related Techniques for Pharmaceutical and Biomedical Analysis
Author: Hiroyuki Kataoka1
Source: Current Pharmaceutical Analysis, Volume 1, Number 1, January 2005 , pp. 65-84(20)
Publisher: Bentham Science Publishers
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Abstract:
Sample preparation is essential for isolating desired components from complex matrices and greatly influences their reliable and accurate analysis. Solid-phase microextraction (SPME) is a new and effective sample preparation technique. Fibers and capillary tubes coated with an appropriate stationary phase are usually used for SPME, but alternative microextraction techniques, including solid-phase dynamic extraction using an internal coated needle, microextraction in a packed syringe and stir-bar-sorptive extraction using a coated magnetic stir bar, have been developed recently. These techniques, in combination with gas chromatography (GC), GC-mass spectrometry (GC-MS), high performance liquid chromatography (HPLC), LC-MS or capillary electrophoresis, can be used for analysis for complex mixtures. These microextraction techniques save preparation time, as well as solvent purchase and disposal costs. This review summarizes recent advances in SPME and related microextraction techniques and their applications in pharmaceutical and biomedical analysis.Keywords: sample preparation for drug analysis; solid-phase microextraction; in-tube solid-phase microextraction; solid-phase dynamic extraction; microextraction in a packed syringe; stir-bar-sorptive extraction
Document Type: Review article
DOI: 10.2174/1573412052953373
Affiliations: 1: School of Pharmacy, Shujitsu University, Nishigawara, Okayama 703-8516, Japan.
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