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Physicochemical Profiling by Capillary Electrophoresis

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Abstract:

The physicochemical properties of pharmaceuticals such as acid dissociation constant (pK), octanol-water partition coefficient (logP), protein binding constant, inclusion complex constant with cyclodextrin (CD), and selfassociation are very important in drug design, candidate selection, and drug delivery. Capillary electrophoresis (CE) is a simple, versatile, automated, and powerful separation technique and widely applied in physicochemical profiling for pharmaceuticals. It has advantages over traditional potentiometric, spectrophotometric, chromatographic, and other methods, as CE requires very small amounts of sample and can measure compounds with impurities and low aqueous solubility. Principles and applications of CE in profiling various physicochemical properties will be reviewed.

Keywords: acid dissociation constant; capillary electrophoresis; drug-protein binding; inclusion complex constant; octanol-water partition coefficient; self-association

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/1573412052953319

Affiliations: Department of Pharmaceutics, Roche Palo Alto, LLC, 3431 Hillview Avenue, M / S R1-3, Palo Alto, CA 94304, USA.

Publication date: January 1, 2005

More about this publication?
  • Current Pharmaceutical Analysis publishes authoritative reviews, written by experts in the field on all the most recent advances in pharmaceutical and biomedical analysis. All aspects of the field are represented including drug analysis, analytical methodology and instrumentation. The journal is essential to all involved in pharmaceutical, biochemical and clinical analysis.
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