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Dissecting Virus-Plant Interactions Through Proteomics Approaches

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Plant viruses exploit cellular factors, including host proteins, membranes and metabolites, for their replication in infected cells and to establish systemic infections. Besides traditional genetic, molecular, cellular and biochemical methods for studying plant-virus interactions, both global and specialized proteomics methods are emerging as useful approaches for the identification of all the host proteins that play roles in virus infections. The various proteomics approaches include measuring differential protein expression in virus-infected versus noninfected cells, analysis of viral and host protein components in the viral replicase or other virus-induced complexes, as well as proteome-wide screens to identify host protein - viral protein interactions using protein arrays or yeast two-hybrid assays. In this review, we will discuss the progress made in plant virology using various proteomics methods, and highlight the functions of some of the identified host proteins during viral infections. Since global proteomics approaches do not usually identify the molecular mechanisms of the identified host factors during viral infections, additional experiments using genetics, biochemistry, cell biology and other approaches will often prove necessary to characterize the functions of host factors. Overall, the everimproving proteomics approaches promise further understanding of plant-virus interactions that will likely result in new strategies for viral disease control in plants.

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Keywords: Arabidopsis thaliana; AtHsc70-3; Beet necrotic yellow vein virus; Beta-1,3-Endoglucanase; Brome mosaic virus; Cucumber necrosis virus; Cyclophilins; Cyclosporin Asensitive proline rotamase 1; Nicotiana benthamiana; PABP; Potato virus X; Proteome; REACTOME; RNA binding; Rab11 GTPase; Rice yellow mottle Virus; Tobacco mosaic virus; Tomato Mosaic virus; Tomato bushy stunt virus; Turnip mosaic virus; Ubiquitin; bimolecular fluorescence complementation assay; clamp adenine motif; eukaryotic translational elongation factor EF-1 alpha (eEF1A); glyceraldehyde-3-phosphate dehydrogenase; heat shock cognate 70-3; host factors; host-virus interaction; mRNAbinding protein; pepper mild mottle virus; plant; potyvirus RNA dependent RNA polymerase; protein microarray; protein-protein interaction; pyruvate decarboxylase; ribonucleoprotein; virus; virus replication

Document Type: Research Article

Publication date: 2010-12-01

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  • Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.
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