Authors: Oien, Derek B.; Wang, Xinkun; Moskovitz, Jackob

Source: Current Proteomics, Volume 5, Number 2, July 2008 , pp. 96-103(8)

Publisher: Bentham Science Publishers

Abstract:

In this review we describe the effects of methionine sulfoxide reductase A (MsrA) ablation in mouse tissues on the expression of various mRNAs and proteins, with an emphasis on brain tissues. Initially, the expression / activity levels of preselected proteins relevant to the methionine sulfoxide reductase system in various tissues are discussed (the list of proteins contains: thioredoxin, thioredoxin reductase, methionine sulfoxide reductase B, glucose-6-phosphate dehydrogenase, gluthathione peroxidase, selenoprotein P, and cysteine dioxygenase). Additionally, the consequences from lack of MsrA on protein oxidation (carbonylation and methionine oxidation) are evaluated. Finally, newly generated unpublished data is presented on genomic and proteomic analyses, compared between MsrA-/- and wild-type control brains. The gathered information is sorted out into three major protein groups that are linked to: 1) oxidative stress / apoptosis / degradation; 2) neuroregulation; and 3) signal transduction / transcription / elongation factors. In summary, the importance and relevance of MsrA in protecting against the development and progression of neurodegenerative diseases is reviewed.

Keywords: Methionine oxidation; methionine sulfoxide reductase; oxidative stress; selenoprotein; antioxidant

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157016408784911891

Publication date: 2008-07-01

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• Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.

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