Possibilities of Two-Dimensional Gel Electrophoresis in the Understanding of Human Disease

Authors: Lopez, Jose L.; Bermudez-Crespo, Jose

Source: Current Proteomics, Volume 4, Number 4, December 2007 , pp. 187-197(11)

Publisher: Bentham Science Publishers

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Abstract:

Because of the multifactorial nature of many diseases, two-dimensional electrophoresis is a basic proteomics tool for its ability of simultaneously detecting post-and co-translational modifications, which cannot be predicted from genome sequences.

This review describes the central role of proteomics tool, two-dimensional electrophoresis for clinical biomarker discovery, the identification of prognostic and diagnostic markers, their use in monitoring the effects of drug treatments and eventually finding more efficient and safer therapeutics for a wide range of pathologies.

Keywords: Proteomics; two-dimensional electrophoresis; biomarker discovery; drug discovery; clinical applications

Document Type: Research article

Publication date: 2007-12-01

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Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.