Authors: Goel, Arvind; Rakwal, Randeep; Agrawal, Ganesh K.

Source: Current Proteomics, Volume 4, Number 3, October 2007 , pp. 174-181(8)

Publisher: Bentham Science Publishers

Abstract:

Cardiac hypertrophy, interstitial fibrosis, and cardiac dysfunction ultimately lead to cardiac failure. Cardiac failure is one of the major causes of heart disease and death in our society. The molecular causes of heart diseases, like many other diseases, remain largely unknown. Recently, large-scale proteomics studies have been undertaken to better understand the underlying mechanisms of molecular causes of heart disease. Many protein alterations have already been identified in the human diseased myocardium. Further experiments on these proteins are ongoing to know their suitability for drug targets, therapeutic proteins, or disease biomarkers. This review deals with a proteomics perspective on human heart failure, and is divided into two parts. The first part provides a glimpse on proteomics technologies used for identification and quantification of proteins related to heart disease. The second part is the main focus of this review and deals with evolving biomarkers and clinical diagnostics, potential future drugs, clinical approaches in managing heart failure, and clinical shortcomings, which are discussed to some detail from the viewpoint of a medical doctor and proteomics scientists.

Keywords: Cardiac proteomics; human disease; two-dimensional gel electrophoresis; mass spectrometry; biomarkers; review

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157016407783221303

Publication date: 2007-10-01

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• Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.

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