Potential Targets of P. acnes for New Treatments of P. acnes-Associated Diseases

Authors: Nakatsuji, Teruaki; Huang, Chun-Ming

Source: Current Proteomics, Volume 4, Number 3, October 2007 , pp. 157-161(5)

Publisher: Bentham Science Publishers

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Abstract:

Increasing evidence demonstrated that Propionibacterium acnes (P. acnes) plays a central role in many human polymicrobial diseases including acne vulgaris, which afflicts more than one million people in the U.S. alone. To date, there are no appropriate therapeutic modalities that effectively control P. acnes succession during disease development. By taking advantage of the availability of genome and proteome of P. acnes, we have highlighted here the events of P. acnes adhesion and biofilm formation as potential targets for development of drugs or vaccines counteracting P. acnesassociated diseases.

Keywords: Propionibacterium acnes; acne; vaccine; lipase; biofilm; bacterial adhesion

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157016407783221295

Publication date: 2007-10-01

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Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.