Quantitative Proteomic Approaches to Investigate the Membrane Proteome in Neuropsychiatric Disorders

Authors: Chan, Man K.; Bahn, Sabine

Source: Current Proteomics, Volume 4, Number 3, October 2007 , pp. 131-140(10)

Publisher: Bentham Science Publishers

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Abstract:

Disease and drug-related alterations in the brain membrane proteome are of particular interest for investigations into neuropsychiatric disorders. Despite decades of research into neurotransmitters and their receptors, our understanding of complex neuropsychiatric disorders has failed to advance substantially. Therefore, global membrane protein profiling studies that are non-hypothesis driven and exploratory are a complementary approach to elucidate the underlying pathomechanisms associated with psychiatric disorders. Although membrane proteins play critical roles in almost all cellular processes, their unique biochemical properties have challenged current quantitative proteomics approaches. The aim of the present review is to critically evaluate and discuss the use and applicability of current quantitative proteomic platforms, sample preparation methods and statistical tools in view of their application to membrane proteome analysis of brain tissue.

Keywords: Neuropsychiatric disorders; quantitative proteomics; membrane proteins; brain tissue

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157016407783221321

Publication date: 2007-10-01

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Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.