Phosphoproteomics: Challenges and Opportunities

Authors: Lee, Kimberly A.¹; Means, Gary D.¹; Patterson, Scott D.¹

Source: Current Proteomics, Volume 3, Number 4, December 2006 , pp. 249-257(9)

Publisher: Bentham Science Publishers

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Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.

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Abstract:

Signal transduction through reversible protein phosphorylation plays a central role in cellular physiology in both normal and disease states, and mass spectrometry is well-suited to the task of identifying and cataloging protein phosphorylation sites. Recent advances in sample enrichment strategies, instrumentation, and software availability allow researchers to identify hundreds of phosphorylation sites in a single study. However, to take the next step toward translating these findings into clinical application, the biological relevance of the sites must be validated and clinical assays must be developed to monitor phospho-specific biomarkers.

Keywords: Phosphoproteomics; biomarker discovery; mass spectrometry; Phosflow™

Document Type: Research article

DOI: 10.2174/157016406780655559

Affiliations: 1: Amgen Inc., Mail Stop AW2/D3152, 1201 Amgen Ct. W, Seattle, WA 98119, USA.