Authors: Poljak, Anne; Sachdev, Perminder; Smythe, George A.

Source: Current Proteomics, Volume 3, Number 2, July 2006 , pp. 81-112(32)

Publisher: Bentham Science Publishers

Abstract:

Proteomics has become a powerful tool facilitating hypothesis-driven exploration of disease states as well as offering a global approach which can uncover potentially important, though unexpected links to disease etiology. Despite many recent advances, the pathophysiological basis of Alzheimer's disease is incompletely understood. Alzheimer's dementia almost certainly results from a constellation of cellular changes, with considerable interplay between multiple genetic and environmental factors. As a multifactorial disease, it is an ideal candidate for a proteomics approach which offers a broad spectrum view of changes to protein expression. The use of proteomics in the study of Alzheimer's dementia is in its early days. However, its importance as an approach to the study of this disease has been recognized by a considerable number of review papers on this topic. This review summarises the advances that proteomics has so far offered to understanding the basis of Alzheimer's pathology. Further, the use of proteomics to explore potential biomarkers of Alzheimer's pathology which might be of clinical or diagnostic use, will be addressed.

Keywords: amyloid precursor protein (APP); MALDI-TOF; Neurofibrillary tangles; MS/MS quantification; cerebrospinal fluid (CSF); Functional Proteomics

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157016406778194635

Affiliations: 1: Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, Australia.

Publication date: 2006-07-01

More about this publication?

• Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.

Related content

• In this: publication
• By this: publisher
• In this Subject: Genetics
• By this author: Poljak, Anne ;  Sachdev, Perminder ;  Smythe, George A.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers