The Computational Versatility of Proteomic Signaling Networks

Author: Sauro H.M.

Source: Current Proteomics, Volume 1, Number 1, January 2004 , pp. 67-81(15)

Publisher: Bentham Science Publishers

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Abstract:

Almost all proteomic signaling networks in prokaryotes and eukaryotes are based on the simple phosphorylation / dephosporylation cycle; from this simple unit it is possible to construct a huge variety of control and computational circuits, both analog and digital. With the characterization of many signaling networks, researchers are turning to address the question of how a particular physiological response can be understood in terms of the proteins that make up the network; this is one of the central questions in “Systems Biology”. In this article I wish to summarize the great versatility of the basic protein cycle as a means to construct complex functional behaviors including the central role that feedback plays in determining the properties of protein based networks.

Keywords: Proteomic Signaling; prokaryotes; eukaryotes

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570164043488315

Affiliations: 1: Control and Dynamical Systems, California Institute of Technology, Pasadena, CA, 91125, USA.

Publication date: 2004-01-01

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Current Proteomics research in the emerging field of proteomics is growing at an extremely rapid rate. The principal aim of Current Proteomics is to publish well-timed review articles in this fast-expanding area on topics relevant and significant to the development of proteomics. Current Proteomics is an essential journal for everyone involved in proteomics and related fields in both academia and industry.