Authors: Salvador, Jorge A.R.; Pinto, Rui M.A.; Silvestre, Samuel M.

Source: Current Organic Synthesis, Volume 6, Number 4, November 2009 , pp. 426-470(45)

Publisher: Bentham Science Publishers

Abstract:

The use of bismuth(III) salts in organic synthesis has attracted an increasing interest over the last years. Systems comprising of bismuth(III) salts are generally catalytic and involve a relatively non-toxic metal. These features are of great interest in the area of green and pharmaceutical chemistry. Due to the fact a large number of natural compounds and known drugs are heterocycles, their construction and/or functionalization is of major interest. This review will focus on the uses of bismuth(III) salts in heterocyclic chemistry, as applied to the synthesis of compounds of pharmaceutical interest. In addition to the inclusion of five- and six-membered heterocycles, five- and six-membered heterocycles fused to one benzene ring, as well as other heterocyclic compounds, the application of bismuth(III) salts to chemistry of carbohydrates, nucleosides and β-lactams will also be considered.

Keywords: Bismuth(III) salts; heterocycles; pharmaceutical interest; green chemistry

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017909789108701

Publication date: 2009-11-01

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• Current Organic Synthesis publishes in-depth reviews on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.

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