Solid-Supported Ammonium Fluorides in Organic Synthesis

Authors: Fringuelli, F.; Lanari, D.; Pizzo, F.; Vaccaro, L.

Source: Current Organic Synthesis, Volume 6, Number 2, May 2009 , pp. 203-218(16)

Publisher: Bentham Science Publishers

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Abstract:

The use of fluoride ion as a base and nucleophile has been widely exploited in organic synthesis. On the other hand over the last few decades the fast-growing development of polymer supported reagents has led to the synthesis of a variety of fluorides on solid support. Such compounds display some major benefits: i.e they are less hygroscopic, easy to recover and to recycle. Tetraalkylammonium fluorides represent some of the most common available sources of fluoride, their solid-supported analogues have been employed in a large range of organic reactions.

Keywords: Tetraalkylammonium fluoride; solid-supported organo catalyst; polymer-supported fluoride; ion-exchange resin; amberlyst A-26 fluoride form

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017909788167284

Publication date: 2009-05-01

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Current Organic Synthesis publishes in-depth reviews on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.