Chemistry of Norbornane/ene and Heteronorbornane/ene β-Amino Acids

Authors: Csende, Ferenc; Fulop, Ferenc; Stajer, Geza

Source: Current Organic Synthesis, Volume 5, Number 2, May 2008 , pp. 173-185(13)

Publisher: Bentham Science Publishers

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Abstract:

The structures, biological properties, preparations and synthetic applications of norbornane/ene bicyclic and heteroatombridged β-amino acids are discussed. These compounds are rare and unique β-alanine derivatives which can be used as bifunctional synthons for the preparation of heterocycles. Through peptidation, they form oligopeptide-like molecules with special helical structures.

Keywords: (Hetero)bicyclic β-amino acids; biological activity; heterocycles; retro diels-alder reactions; ugi reactions; peptide syntheses

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017908784221576

Publication date: 2008-05-01

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Current Organic Synthesis publishes in-depth reviews on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.