Recent Developments in the Synthesis of Amino Acids and Analogues for Foldamers Study

Author: Haldar, Debasish

Source: Current Organic Synthesis, Volume 5, Number 1, February 2008 , pp. 61-80(20)

Publisher: Bentham Science Publishers

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Abstract:

Synthetic amino acids have particular appeal for extending our understanding of protein structure and stabilization into the realm of folded, nonbiological polymers. Chemists are now beginning to design biomimetic amino acids that can form both secondary and tertiary structures. An overview of the synthesis of non-protein amino acids recently used in the design of conformationally welldefined foldamers is discussed.

Keywords: Nonproteinogenic amino acids; amino acids analogues; synthesis; foldamers

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157017908783497527

Publication date: 2008-02-01

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Current Organic Synthesis publishes in-depth reviews on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.