Recent Progress in the Chemistry of Allenes

Author: Hassan, Hammed H.A.M.

Source: Current Organic Synthesis, Volume 4, Number 4, November 2007 , pp. 413-439(27)

Publisher: Bentham Science Publishers

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Abstract:

Allenes are important compounds in organic and synthetic organic chemistry and therefore a large number of studies on their synthesis and reactions have been reported so far. We report the most recent methods for the synthesis of allenes, including optically active forms and fluorinated and gem-difluorinated allenes, in this paper. Reactions such as nucleophilic addition of allenes were classified and discussed in details according to the nature of the nucleophile either oxygen, nitrogen, carbon or sulfur, whereas, inter- and intra-molecular cycloadditions reactions with a variety of unsaturated functionality were separately discussed. A collection of some useful reactions such as coupling reactions of allenes mediated by organometallic reagents, intramolecular cyclization of allenes with tethered amines, asymmetric dihydroxylation, and epoxidation of allenes are also included.

Keywords: Fluorinated allenes; electronic spectrum; synthesis; cycloadditions; intramolecular; nucleophiles

Document Type: Research article

Publication date: 2007-11-01

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Current Organic Synthesis publishes in-depth reviews on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.