Current Strategies for the Synthesis of RNA

Authors: Muller S.; Wolf J.; Ivanov S.A.

Source: Current Organic Synthesis, Volume 1, Number 3, July 2004 , pp. 293-307(15)

Publisher: Bentham Science Publishers

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Abstract:

The biological potential of RNA along with the variety of possible applications has led to an increased demand for large-scale production of RNA molecules. Recent developments in the field allow for the synthesis of long RNA molecules (up to 100 nts) of excellent quality. This review focuses on current strategies (i.e. 2'-O-TBDMS, 2'-O-TOM and 2'-O-ACE chemistry) for chemical RNA synthesis.

Keywords: oligonucleotides; phosphoramidite; protecting groups; rna; solid phase; synthesis

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570179043366675

Affiliations: 1: Ruhr-Universitat Bochum, Fakultat fur Chemie, AG Bioorganische Chemie, Universitatsstr. 150, 44780 Bochum, Germany

Publication date: 2004-07-01

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Current Organic Synthesis publishes in-depth reviews on all areas of synthetic organic chemistry i.e. asymmetric synthesis, organometallic chemistry, novel synthetic approaches to complex organic molecules, carbohydrates, polymers, protein chemistry, DNA chemistry, supramolecular chemistry, molecular recognition and new synthetic methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by experts who are internationally known for their eminent research contributions. The journal is essential reading to all synthetic organic chemists. Current Organic Synthesis should prove to be of great interest to synthetic chemists in academia and industry who wish to keep abreast with recent developments in key fields of organic synthesis.