A Synthetic Approach and Antimicrobial Evaluation of Annulated Pyrimidine and Triazine Derivatives

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In this Subject: Organic Chemistry
By this author: Aly, A. A.

Author: Aly, A. A.

Source: Current Organic Chemistry, Volume 13, Number 17, November 2009 , pp. 1758-1764(7)

Publisher: Bentham Science Publishers

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Abstract:

A smooth and rapid one step synthesis of novel pyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidines 4a,b and 7, pyrido[2',3':3,4]pyrazolo[5,1-c]triazines10-12a,b, pyrido[3“,2“:4',5']thieno[3',2':4,5]pyrimido/triazino[1,6-a]benzimidazoles 15-20 in synthetically useful yields utilizing, 3-amino-4-phenyl-5-(saccharin-2-yl)-1H-pyrazolo[3,4-b]pyridine (3) were described. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. Preliminary biological studies of some synthesized compounds showed promising antimicrobial activities.

Document Type: Research article

Publication date: 2009-11-01