N-Alkylated Guanine Derivatives

Authors: Ferenc, G.; Padar, P.; Szolomajer, J.; Kovacs, L.

Source: Current Organic Chemistry, Volume 13, Number 11, July 2009 , pp. 1085-1135(51)

Publisher: Bentham Science Publishers

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Abstract:

The synthesis, chemical, physical, biological, spectroscopic and miscellaneous analytical properties of Nalkylguanine derivatives substituted at 1-, 1,N²-, N²-, 3-, 3,N²-, 7-, 7,9- and 9-positions have been surveyed, mainly from the 2003-2009 period. Beyond the synthetic methods, particular emphasis has been given to products of mutagenesis and carcinogenesis, the role of modified fluorescent guanosines (wyosine, wyebutosine), mRNA cap structures and drugs stemming from N-alkylguanines. The review is based on 154 references and contains 64 schemes with 355 numbered structures.

Keywords: Nalkylguanine; Derivatives; synthesis; mutagenesis; carcinogenesis

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138527209788680718

Publication date: 2009-07-01