Recent Progress on the Synthesis of Trifluoromethylated Heterocyclic Compounds Based on ethyl 4, 4, 4-trifluoroacetoacetate and its Derivatives

Authors: Zhu, Shizheng; Song, Liping; Jin, Guifang; Dai, Baifan; Hao, Jian

Source: Current Organic Chemistry, Volume 13, Number 10, July 2009 , pp. 1015-1027(13)

Publisher: Bentham Science Publishers

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Abstract:

This review highlights some of the recent progress that has been made in our laboratory and others in the field of trifluoromethylated (CF3) heterocyclic compounds starting from CF3-containing building blocks. Under mild reaction conditions, ethyl 4,4,4-trifluoroacetoacetate and its derivatives reacted with various organic reagents to produce CF3- containing N, O, S-heterocycles.

Keywords: Synthesis; trifluoromethylated (CF3); ethyl 4, 4, 4-trifluoroacetoacetate; Derivatives; organic reagents

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138527209788680772

Publication date: 2009-07-01