Author: Guan, Hairong

Source: Current Organic Chemistry, Volume 12, Number 16, November 2008 , pp. 1406-1430(25)

Publisher: Bentham Science Publishers

Abstract:

This review presents current strategies of using titanium and zirconium reagents to achieve umpolung of carbonyl and imine functionalities. The reactions of organometallic compounds, including those that are equivalent to acyl anions, α-amino carbanions, α-hydroxy carbanions, and homoenolates, are among the most powerful methods to form carbon-carbon bonds. The remarkable chemoselectivity, regioselectivity, and stereoselectivity observed in many cases once more demonstrate great synthetic application of organotitanium and organozirconium compounds.

Keywords: reagents; titanium; zirconium; Umpolung Reactions; organometallic compounds; chemoselectivity; stereoselectivity

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138527208786241529

Publication date: 2008-11-01

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