The Synthesis of Disaccharides, Oligosaccharides and Analogues Containing Thiosugars

Authors: Robina I.; Vogel P.

Source: Current Organic Chemistry, Volume 6, Number 5, April 2002 , pp. 471-491(21)

Publisher: Bentham Science Publishers

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Abstract:

Disaccharide and oligosaccharide mimics are potentially more selective glycosidases inhibitors than simple monosaccharide mimics. They represent also more selective ligands for lectins and oligosaccharide receptors and can become immunostimulating agents. The biological properties of disaccharide and oligosaccharide analogs containing thiosugars (5-thiopyranoses, 4-thiofuranoses) are revised together with the methods for their obtention.

Keywords: thiosugars; clathria pyramida; salacia reticulata; enzymatic glycosylations; chemical glycosylationas; schmidt trichloroacetimidate; thiofucosidations; koenigs-knorr thioarabinosidation; thioglycosylamines; radical c-thioglycosylation

Language: English

Document Type: Review article

DOI: 10.2174/1385272024604952

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