In Vitro Polyester Synthesis via Enzymatic Polymerization

Authors: Kobayashi S.; Uyama H.

Source: Current Organic Chemistry, Volume 6, Number 2, February 2002 , pp. 209-222(14)

Publisher: Bentham Science Publishers

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Abstract:

Recent topics on in vitro synthesis of polyesters by mainly lipase catalysis are reviewed. Lipase, an enzyme catalyzing an ester bond-cleavage reaction by water in living cells, induces the reverse reaction of hydrolysis, leading to polymer production by a bond-forming reaction. Polyester synthesis has been achieved from various monomer combinations, typically oxyacids or their esters, dicarboxylic acids or their derivatives / glycols, and lactones under mild reaction conditions. Lipase catalyzes ring-opening polymerization of lactones and their enzymatic polymerizability is quite specific in comparison with that by conventional chemical catalysts. Enzymatic synthesis of end-functional polyesters by facile procedures has been developed. By utilizing characteristic catalytic function of lipases, regio- and enantioselective polymerizations proceed to give functional polymers, many of which are difficult to be synthesized by conventional methodologies.

Keywords: Polyester Synthesis; Enzymatic Polymerization; ester bond-cleavage reaction; enantioselective polymerizations; 3-methyl-4-oxa-6-hexanolide (MOHEL); Chemoenzymatic synthesis; azelaic anhydride; Enantiomeric excess; 16-Hexadecanolide; Porcine pancrease lipase

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1385272023374544

Publication date: 2002-02-01