Multivalent Binding in the Design of Bioactive Compounds

Authors: Wright D.; Usher L.

Source: Current Organic Chemistry, Volume 5, Number 11, November 2001 , pp. 1107-1131(25)

Publisher: Bentham Science Publishers

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

Over the past several years, much research has centered on the development of small molecules that, through multivalent binding interactions, enhance the regulation of fundamental biological functions. The design of a wide range of potential therapeutics focuses on mimicking natural systems that control the biological effect of protein-ligand interactions through multivalency. In this review, the various approaches to achieving multivalency are discussed. Recent advances in the design of multivalent ligands are also presented.

Keywords: Multivalent Binding; Bioactive Compounds; MULTIVALENT LIGANDS; adrenoreceptor; Conjugate addition; homobifunctional molecule; matrixmetalloproteinase; lipophiclic domain; membrane-docking protein; embryogenesis; Salmeterol

Language: English

Document Type: Review article

DOI: 10.2174/1385272013374806

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$55.10 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A