Multivalent Binding in the Design of Bioactive Compounds

Authors: Wright D.; Usher L.

Source: Current Organic Chemistry, Volume 5, Number 11, November 2001 , pp. 1107-1131(25)

Publisher: Bentham Science Publishers

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Abstract:

Over the past several years, much research has centered on the development of small molecules that, through multivalent binding interactions, enhance the regulation of fundamental biological functions. The design of a wide range of potential therapeutics focuses on mimicking natural systems that control the biological effect of protein-ligand interactions through multivalency. In this review, the various approaches to achieving multivalency are discussed. Recent advances in the design of multivalent ligands are also presented.

Keywords: Multivalent Binding; Bioactive Compounds; MULTIVALENT LIGANDS; adrenoreceptor; Conjugate addition; homobifunctional molecule; matrixmetalloproteinase; lipophiclic domain; membrane-docking protein; embryogenesis; Salmeterol