The Utility of Nitroacetic Acid and its Derivatives in the Synthesis of Heterocycles

Authors: Kislyi V.V.; Samet A.V.; Semenov V.V.

Source: Current Organic Chemistry, Volume 5, Number 5, May 2001 , pp. 553-570(18)

Publisher: Bentham Science Publishers

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Abstract:

Heterocycles, bearing nitro groups, are of interest as biologically active compounds (e.g., metronidazole, nitrazepam, nitroxolinum) or in connection with hydrogenation of nitro- to amino group. Methods of nitration are not always satisfactory because of low yields, mixture of isomers formation and potential hazard of nitrating reagents. The application of nitroacetic acid derivatives has been previously reviewed in part (1-5). The present review summarizes data reported after 1980 but older work is also cited when appropriate.

Keywords: Nitroacetic Acid; tert-butyl esters; anti-histamine activity; Lawesson reagent; genuine amidines

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1385272013375445

Publication date: 2001-05-01

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