Synthesis and Reactivity of 7-Azaindoles (1H-Pyrrolo(2,3-b)pyridine)

Authors: Merour J-Y.; Joseph B.

Source: Current Organic Chemistry, Volume 5, Number 5, May 2001 , pp. 471-506(36)

Publisher: Bentham Science Publishers

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Abstract:

The results of research into the chemistry of 7-azaindole during the last twenty years are presented. New synthetic methods for the 7-azaindole structures are developed including palladium-catalysed cross-coupling reactions. Reactivity of 3-formyl-, 3-halogeno- and 2-lithio-7-azaindole derivatives is reported. Functionalisation of the pyridine ring via the N-oxide is also described. In the last part, biological activity of various 7-azaindole derivatives is briefly indicated.

Keywords: Azaindoles; palladium-catalysed; cross-coupling reactions; Kirkpatrickia varialosa; pyrrolo annelation; heteroatomic rings; butylcarbonylaminopyridine; photo-Graebe-Ullmann; intramolecular cyclisation; iminophosphorane moiety.; functionalised aldehyde; iodomethame; monobrominated