Significance of Total Synthesis of Bioactive Compounds

Author: Tatsuta K.

Source: Current Organic Chemistry, Volume 5, Number 2, February 2001 , pp. 207-231(25)

Publisher: Bentham Science Publishers

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Abstract:

The first total synthesis and development of a variety of bioactive compounds have been accomplished mainly by using carbohydrates, if any, as chiral sources. The target molecules are macrolide antibiotics, aminoglycoside antibiotics, antifungal antibiotics, antitumor antibiotics, a side-chain of b-lactam antibiotics, enzyme inhibitors including glycosidase inhibitors, central nervous system - affecting products, nonsteroidal progesterone receptor ligands, mussel-attachment inhibitors and so on.

Keywords: Total synthesis; aminoglycoside antibiotics; macrolide; enzyme inhibitors; ansa; oleandomycin; Cyclophellitols; Glyoxalase; Syncytium formation; terpestacin

Language: English

Document Type: Review article

DOI: 10.2174/1385272013375670

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