DNA Polymerase Structure and Mechanisms of Action

Authors: Hingorani M.M.; O'Donnell M.

Source: Current Organic Chemistry, Volume 4, Number 9, September 2000 , pp. 887-913(27)

Publisher: Bentham Science Publishers

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Abstract:

The ubiquitous and essential nature of DNA predicts that enzymes responsible for DNA synthesis evolved early and share a common design and mechanism of action. DNA polymerases from many different organisms do exhibit striking similarities in their overall architecture, the design of the catalytic site, and the mechanism of nucleotidyl transfer. In spite of these shared features, however, DNA polymerases display an astonishing variety in structure and function, ranging The ubiquitous and essential nature of DNA predicts that enzymes responsible for DNA synthesis evolved early and share a common design and mechanism of action. DNA polymerases from many different organisms do exhibit striking similarities in their overall architecture, the design of the catalytic site, and the mechanism of nucleotidyl transfer. In spite of these shared features, however, DNA polymerases display an astonishing variety in structure and function, ranging

Keywords: DNA Polymerse; Enzymes; DNA synthesis; Genomic DNA replication; DNA metabolism; Cell cycle regulation; Saccharomyces cerevisiae; Pyrococcus furiosus; DP2 family; E. coli Pol I; Klentaq1 polymerase; DNA editing; Holoenzyme; DNA replisome; Monomeric tethers