Bioactive Marine Alkaloids

Authors: Urban S.; Hickford S.J.H.; Blunt J.W.; Munro M.H.G.

Source: Current Organic Chemistry, Volume 4, Number 7, July 2000 , pp. 765-807(44)

Publisher: Bentham Science Publishers

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Abstract:

The structures, origins, biogenesis, synthesis and bioactivity of a selection of N-heterocyclic marine alkaloids are reviewed. The emphasis is on compounds poised as potential anticancer drugs: lamellarins (pyrroles), cephalostatins/ritterazines (pyrazines) and ecteinascidins (isoquinolines). Also discussed are examples of bioactive marine alkaloids that have emerged as novel leads. These include manzamines (beta-carbolines), variolins (pyridopyrrolopyrimidines) and the pyrroloquinoline family. This review emphasises the role of marine alkaloids as an important source of leads for drug discovery.

Keywords: Bioactive marine alkaloids; N-heterocyclic marine alkaloids; Anticancer drugs; Lamellarins; Cephalostatins; Pyrroles; Ritterazines; Pyrazines; Ecteinascidins; Isoquinolines; Manzamines; Beta carbolines; Viriolins; Pyridopyrrolopyrimidines; Pyrroloquinoline; Didemnum chartaceum; Lamellaria; Pyrrole alkaloids; Ningalins; Lukianols; Rigidin; Storniamides; Tyrosine derived pyrrole alkaloids; Biogenesis