Cyclodextrins to Increase the Utility of Enzymes in Organic Synthesis

Authors: Harper J.B.; Easton C.J.; Lincoln S.F.

Source: Current Organic Chemistry, Volume 4, Number 4, April 2000 , pp. 429-454(26)

Publisher: Bentham Science Publishers

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Abstract:

The use of cyclodextrins to facilitate enzyme-catalysed processes is reviewed. The effects of the host molecules are discussed with specific attention paid to increasing the availability of insoluble substrates, reducing substrate inhibition and limiting product inhibition. In each case, the effects of the cyclodextrins are interpreted in terms of the formation of inclusion complexes. It is thus demonstrated that cyclodextrins can be used in a rational fashion to increase the utility of enzymes in organic synthesis.

Keywords: Cyclodextrins; Enzymes; Organic synthesis; Substrate inhibition; Product inhibition; Chaperones; Enzyme catalysed processes; Mucuna pruriens; Penicillium raistrickii; Crocus sativus; Stereoselective reduction; Podophykllum hexandrum; Linum flavum; Arthrobater globiformis; Mycobacterium smegmatis; Mycobacterium phlei; S phenylalanine ammonia; Selective guest binding; Palmitoyl CoA; Glucose 6 phosphate dehydrogenase; Aminocyclodextrin