Synthetic Approaches to the Eudistomin Marine Alkaloids

Authors: McNulty J.; Still I.W.J.

Source: Current Organic Chemistry, Volume 4, Number 2, February 2000 , pp. 121-138(18)

Publisher: Bentham Science Publishers

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Abstract:

The isolation, structure determination and biological evaluation of the eudistomin alkaloids, isolated mainly from marine tunicates of the genus Eudistoma, is described. The compounds are placed in a well defined unique structural class based upon biogenic considerations. The methods which have been employed towards total synthesis of these metabolites are reviewed in detail.

Keywords: Eudistomin marine alkaloids; Marine tunicates; Eudistoma; Marine natural products; Anticancer; Antibacterial; Antiviral activities; Dolabella; Auricularia; Bugula neritina; Ecteinascidia; Cancer; Lissoclinum fragile; Pseudodistoma aureum; Synthesis; Cysteine derived; Eudistomins; Eudistomidins; Glutamate; Proline derived; Beta carbolines