Phenotypic Screening Strategies for Neurodegenerative Diseases: A Pathway to Discover Novel Drug Candidates and Potential Disease Targets or Mechanisms
Keywords: Alzheimer's disease; Analgesia; BDNF; C. elegans; Diabetes; Dyslipidemia; Eflornithine; Huntington's disease; Motor neuron disease; Olesoxime; PREDICT-HD; Parkinson's disease; Rogain; TRO19622; Viagra; amyotrophic lateral sclerosis; black-box; cell-based assays; chemical genetics; chemotherapy-induced neuropathy; drosophila; drug discovery; electroporation; epilepsy; mPTP; mitochondrial dysfunction; olesoxime; phenotypic screening; phenotypic screening assays; riluzole; spinal muscular atrophy
Document Type: Research Article
Publication date: 2010-12-01
- CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will contain a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in neurological and CNS disorders. As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.