Organelle Stress Sensors and Cell Death Mechanisms in Neurodegenerative Diseases
Keywords: (SCA2); A-binding alcohol dehydrogenase; AMPA; Alzheimer's disease; Apoptosis; BDNF; CALNUC; CREB-binding protein; Down's syndrome; Drosophila huntingtin; Extrinsic apoptotic pathway activation; Fas-mediated apoptosi; GSK3; Huntington's disease; Minocycline; NMDA; PCD pathway; PERK-EIF2; Parkinson's disease; Programmed cell death; Rosiglitazone; SERCA; TNFR1; TUDCA; amyotrophic lateral sclerosis; anterograde transport; apoptosis inducing factor; autophagy; cell death; cell signaling; cerebellar degeneration; cyclosporin A; excitotoxicity; neurodegeneration; neuroprotection; organelles; permeability transition pore; phagolysosomes; phosphatidylserine; point-of-no-return; presenilin; rapamycin; retinitis pigmentosa; sphingomyelin; spinal muscular atrophy; stress sensors
Document Type: Research Article
Publication date: 01 December 2010
- CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will contain a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in neurological and CNS disorders. As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.