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Neurological Disorders in Mice Lacking Glycogenes that are Mainly Expressed in Brain

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At the present time, 160 human glycogenes encoding glycosyltransferases and sulfotransferases, which add sulfate to carbohydrates, have been cloned and analyzed for their substrate specificity. Mice have almost all genes orthologous to them, and some are specifically expressed in neuronal tissues. In this review, neurological disorders of mice deficient for the glycogenes that synthesize interesting carbohydrate epitopes in neuronal tissues are described and summarized.

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Keywords: Glycogene; HNK-1; Lewis X; ganglioside; glycosyltransferase; knockout mouse; polysialic acid; sulfotransferase

Document Type: Research Article

Affiliations: Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), OSL, Central 2, 1-1-1 Umezono, Tsukuba, Ibaraki, Japan 305-8568.

Publication date: 2006-08-01

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  • CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will contain a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in neurological and CNS disorders. As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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