The Insulin-like Growth Factor-1 Axis and its Potential as a Therapeutic Target in Central Nervous System (CNS) Disorders

Authors: Bibollet-Bahena, Olivia; Cui, Qiao-Ling; Almazan, Guillermina

Source: Central Nervous System Agents in Medicinal Chemistry(Formerly Current Medicinal, Volume 9, Number 2, June 2009 , pp. 95-109(15)

Publisher: Bentham Science Publishers

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Abstract:

The insulin-like growth factor-1 (IGF-1) is a pleiotropic factor. Many studies have revealed its importance in the development and maintenance of the central nervous system (CNS). This review will discuss the IGF-1 axis, from the factor itself to the signalling pathways it activates, and its tight regulation. Particular focus will be brought on potential therapeutic targets of the IGF-1 axis in CNS disorders, including brain tumours and neurodegenerative diseases affecting neurons and oligodendrocytes.

Document Type: Research article

DOI: http://dx.doi.org/10.2174/187152409788452108

Publication date: 2009-06-01

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Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Each issue of the journal will contain a series of timely in-depth reviews written by leaders in the field covering a range of current topics in central nervous system medicinal chemistry.

Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in central nervous system drug discovery.