HspB5/αB-Crystallin: Properties and Current Progress in Neuropathy

Authors: Hu, Zhiping; Li, Ting

Source: Current Neurovascular Research, Volume 5, Number 2, May 2008 , pp. 143-152(10)

Publisher: Bentham Science Publishers

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Abstract:

HspB5/αB-crystallin (αBC), one of the most representative member of mammalian small heat shock protein family (sHsp), shares the common features with other nine members HspB1-B4 and HspB6-10. Meanwhile, it has a strong antiapoptic effect; its interaction with cytoskeleton participates in maintaining cell structure and plays an important role in cytoprotection. Recent studies reveal that HspB5 has a strong relationship with neurological diseases acting as a protective molecular chaperone or in certain conditions, a pathogenic factor. This review gives a brief introduction on properties of HspB5, its current progress in neurological diseases and potential therapeutic intervention in demyelinating disease, neurodegenerative disease, myopathy and cerebrovascular disease.

Keywords: HspB5/αB-crystallin; property; apoptosis; cytoskeleton; neurological disease; multiple sclerosis; ischemia/reperfusion injury; therapeutic intervention

Document Type: Research article

Publication date: 2008-05-01

More about this publication?

Current Neurovascular Research (CNR) provides a cross platform for the publication of scientifically rigorous research that addresses disease mechanisms of both neuronal and vascular origins in neuroscience. The journal serves as an international forum for the publication of novel and pioneering original work as well as timely neuroscience research reviews in the disciplines of cell developmental disorders, plasticity, and degeneration that bridge the gap between basic science research and clinical discovery. CNR emphasizes the elucidation of disease mechanisms, both cellular and molecular, which can impact the development of unique therapeutic strategies for neuronal and vascular disorders.