“SLY AS A FOXO”: New Paths with Forkhead Signaling in the Brain

Authors: Maiese, Kenneth; Chong, Zhao Z.; Shang, Yan C.h.e.n.

Source: Current Neurovascular Research, Volume 4, Number 4, November 2007 , pp. 295-302(8)

Publisher: Bentham Science Publishers

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Abstract:

The Forkhead transcription factor FOXO3a has emerged as a versatile target for diseases that impact upon neuronal survival, vascular integrity, immune function, and cellular metabolism. Enthusiasm is high to fill a critical treatment void through FOXO3a signaling for several neurodegenerative disorders that include aging, neuromuscular disease, systemic lupus erythematosus, stroke, and diabetic complications. Here we discuss the influence of FOXO3a upon cell survival and longevity, the intricate signal transduction pathways of FOXO3a, insights into present disease models, and the potential clinical translation of FOXO3a signaling into novel therapeutic strategies.

Keywords: Amyotrophic lateral sclerosis; diabetes; apoptosis; FOXO3a; FKHRL1; Akt; erythropoietin; neuromuscular disease; oxidative stress; psychiatric

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156720207782446306

Publication date: 2007-11-01

More about this publication?

Current Neurovascular Research (CNR) provides a cross platform for the publication of scientifically rigorous research that addresses disease mechanisms of both neuronal and vascular origins in neuroscience. The journal serves as an international forum for the publication of novel and pioneering original work as well as timely neuroscience research reviews in the disciplines of cell developmental disorders, plasticity, and degeneration that bridge the gap between basic science research and clinical discovery. CNR emphasizes the elucidation of disease mechanisms, both cellular and molecular, which can impact the development of unique therapeutic strategies for neuronal and vascular disorders.