Authors: Lim, Michael; Cheshier, Samuel; Steinberg, Gary K.

Source: Current Neurovascular Research, Volume 3, Number 3, August 2006 , pp. 237-245(9)

Publisher: Bentham Science Publishers

Abstract:

In the normal adult brain, blood vessel formation is tightly down-regulated. However, pathologic processes such as brain tumors can increase the proportion of endothelial cells involved in angiogenesis. When this process is initiated, a complex series of timed events result in new vessel formation. In this review, we will describe the process of angiogenesis in the central nervous system. We will discuss the roles of Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factor (FGF), Angiopoietins, Platelet Derived Growth Factor (PDGF), and integrins in angiogenesis. We will also look into their significance in disease processes such as neoplasms, arteriovenous malformations (AVM), and Moyamoya disease.

Keywords: Angiogenesis; vasculogenesis; VEGF; FGF; angiopoietins; integrins; AVMs; Moyamoya disease; antiangiogenic therapies

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156720206778018730

Affiliations: 1: Stanford University Hospital,Department of Neurosurgery, Edwards Building R-297, 300 Pasteur Drive,Stanford, CA 94305-5327, USA.

Publication date: 2006-08-01

More about this publication?

• Current Neurovascular Research (CNR) provides a cross platform for the publication of scientifically rigorous research that addresses disease mechanisms of both neuronal and vascular origins in neuroscience. The journal serves as an international forum for the publication of novel and pioneering original work as well as timely neuroscience research reviews in the disciplines of cell developmental disorders, plasticity, and degeneration that bridge the gap between basic science research and clinical discovery. CNR emphasizes the elucidation of disease mechanisms, both cellular and molecular, which can impact the development of unique therapeutic strategies for neuronal and vascular disorders.

Related content

• In this: publication
• By this: publisher
• In this Subject: Neurology & Psychiatry
• By this author: Lim, Michael ;  Cheshier, Samuel ;  Steinberg, Gary K.

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers