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Synthesis, Characterization and Application of Dumbbell-shaped Magnetic (Fe3O4 and γ-Fe2O3) Nanoparticles Against HeLa (Cancer) Cells

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Abstract:

The current study was designed to find out the cancer cell killing efficacy of as-synthesized dumbbell-shaped Fe3O4 and γ- Fe2O3 magnetic nanoparticles under AC (alternating current) magnetic-fields induction condition. Dumbbell-shaped Fe3O4 and γ-Fe2O3 magnetic nanoparticles were successfully prepared by a modified hydrothermal method. Ferrous chloride tetrahydrate was solely used as a precursor for the nanomaterials. The as-synthesized nanomaterials were characterized by using XRD, FE-SEM and TEM. Dumbbellshaped particle morphology was observed for the first time in all of iron oxides with magnetic properties. The particle size observed was 50–60 nm. The synthesized nanomaterials showed acceptable magnetization values when magnetic hysteresis loops were measured using a superconducting quantum interference device (SQUID) as well as colloidal stability. Moreover, the as-prepared magnetic nanoparticles suspensions showed significant temperature increments and cancer (HeLa) cell destroying potentiality (91% and 95% for Fe3O4 and γ- Fe2O3, respectively) under an AC magnetic-field induction condition at room temperature using the concentration of 150 μg/mL.

Keywords: Magnetic materials; cancer cells; cytotoxicity; dumbbell-shaped; heat dissipation; hyperthermia; magnetic-field

Document Type: Research Article

DOI: http://dx.doi.org/10.2174/157341312803989051

Publication date: December 1, 2012

More about this publication?
  • Current Nanoscience publishes authoritative reviews and original research reports, written by experts in the field on all the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano- structures, synthesis, properties, assembly and devices. Applications of nanoscience in biotechnology, medicine, pharmaceuticals, physics, material science and electronics are also covered. The journal is essential to all involved in nanoscience and its applied areas.
ben/cnano/2012/00000008/00000006/art00003
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